TY  - GEN
AU  - Finkelstein,David I
AU  - Billings,Jessica L
AU  - Adlard,Paul A
AU  - Ayton,Scott
AU  - Sedjahtera,Amelia
AU  - Masters,Colin L
AU  - Wilkins,Simon
AU  - Shackleford,David M
AU  - Charman,Susan A
AU  - Bal,Wojciech
AU  - Zawisza,Izabela A
AU  - Kurowska,Ewa
AU  - Gundlach,Andrew L
AU  - Ma,Sheri
AU  - Bush,Ashley I
AU  - Hare,Dominic J
AU  - Doble,Philip A
AU  - Crawford,Simon
AU  - Gautier,Elisabeth Cl
AU  - Parsons,Jack
AU  - Huggins,Penny
AU  - Barnham,Kevin J
AU  - Cherny,Robert A
TI  - The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease
SN  - 2051-5960
PY  - 2017///1219
KW  - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
KW  - Animals
KW  - Antiparkinson Agents
KW  - pharmacology
KW  - Cation Transport Proteins
KW  - metabolism
KW  - Cell Line, Tumor
KW  - Dogs
KW  - Female
KW  - Humans
KW  - Iron
KW  - Male
KW  - Mice, Inbred C57BL
KW  - Mice, Transgenic
KW  - Neurons
KW  - drug effects
KW  - Neuroprotective Agents
KW  - Oxidative Stress
KW  - Oxidopamine
KW  - Parkinsonian Disorders
KW  - drug therapy
KW  - Quinazolinones
KW  - Rats
KW  - Recombinant Proteins
KW  - genetics
KW  - Substantia Nigra
KW  - alpha-Synuclein
KW  - Ferroportin
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1186/s40478-017-0456-2
ER  -