TY  - GEN
AU  - Emery,Caroline M
AU  - Monaco,Kelli-Ann
AU  - Wang,Ping
AU  - Balak,Marissa
AU  - Freeman,Alyson
AU  - Meltzer,Jodi
AU  - Delach,Scott M
AU  - Rakiec,Daniel
AU  - Ruddy,David A
AU  - Korn,Joshua M
AU  - Haling,Jacob
AU  - Acker,Michael G
AU  - Caponigro,Giordano
TI  - BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity
SN  - 1557-3125
PY  - 2018///0618
KW  - Allosteric Site
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - Colorectal Neoplasms
KW  - drug therapy
KW  - Gene Expression Regulation, Neoplastic
KW  - drug effects
KW  - Humans
KW  - MAP Kinase Kinase 1
KW  - chemistry
KW  - MAP Kinase Kinase 2
KW  - MAP Kinase Signaling System
KW  - Models, Molecular
KW  - Mutation
KW  - Phosphorylation
KW  - Protein Kinase Inhibitors
KW  - pharmacology
KW  - Protein Structure, Secondary
KW  - Proto-Oncogene Proteins B-raf
KW  - raf Kinases
KW  - metabolism
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1158/1541-7786.MCR-17-0211
ER  -