TY - GEN AU - O'Reilly,Michael W AU - Kempegowda,Punith AU - Walsh,Mark AU - Taylor,Angela E AU - Manolopoulos,Konstantinos N AU - Allwood,J William AU - Semple,Robert K AU - Hebenstreit,Daniel AU - Dunn,Warwick B AU - Tomlinson,Jeremy W AU - Arlt,Wiebke TI - AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome SN - 1945-7197 PY - 2017///1012 KW - 3-Hydroxysteroid Dehydrogenases KW - metabolism KW - Adipocytes KW - drug effects KW - Adolescent KW - Adult KW - Aldo-Keto Reductase Family 1 Member C3 KW - Analysis of Variance KW - Androgens KW - Area Under Curve KW - Biomarkers KW - blood KW - Case-Control Studies KW - Cells, Cultured KW - Dehydroepiandrosterone KW - pharmacology KW - Female KW - Humans KW - Hydroxyprostaglandin Dehydrogenases KW - Insulin Resistance KW - Lipid Metabolism KW - Lipolysis KW - Polycystic Ovary Syndrome KW - Real-Time Polymerase Chain Reaction KW - methods KW - Reference Values KW - Statistics, Nonparametric KW - Subcutaneous Fat KW - Young Adult N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1210/jc.2017-00947 ER -