TY - GEN AU - Mead,Adam J AU - Neo,Wen Hao AU - Barkas,Nikolaos AU - Matsuoka,Sahoko AU - Giustacchini,Alice AU - Facchini,Raffaella AU - Thongjuea,Supat AU - Jamieson,Lauren AU - Booth,Christopher A G AU - Fordham,Nicholas AU - Di Genua,Cristina AU - Atkinson,Deborah AU - Chowdhury,Onima AU - Repapi,Emmanouela AU - Gray,Nicki AU - Kharazi,Shabnam AU - Clark,Sally-Ann AU - Bouriez,Tiphaine AU - Woll,Petter AU - Suda,Toshio AU - Nerlov,Claus AU - Jacobsen,Sten Eirik W TI - Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation SN - 1540-9538 PY - 2017///1006 KW - Animals KW - Anti-Inflammatory Agents, Non-Steroidal KW - pharmacology KW - Bone Marrow Cells KW - drug effects KW - Bone Marrow Transplantation KW - Cell Proliferation KW - genetics KW - Cells, Cultured KW - Etanercept KW - Gene Expression Profiling KW - methods KW - Hematopoietic Stem Cells KW - Mesenchymal Stem Cells KW - Mice, Inbred C57BL KW - Mice, Transgenic KW - Mutation KW - Reverse Transcriptase Polymerase Chain Reaction KW - Single-Cell Analysis KW - Stem Cell Niche KW - Tandem Repeat Sequences KW - Tumor Necrosis Factor-alpha KW - antagonists & inhibitors KW - fms-Like Tyrosine Kinase 3 N1 - Publication Type: Journal Article UR - https://doi.org/10.1084/jem.20161418 ER -