TY - GEN AU - Delord,Jean-Pierre AU - Robert,Caroline AU - Nyakas,Marta AU - McArthur,Grant A AU - Kudchakar,Ragini AU - Mahipal,Amit AU - Yamada,Yasuhide AU - Sullivan,Ryan AU - Arance,Ana AU - Kefford,Richard F AU - Carlino,Matteo S AU - Hidalgo,Manuel AU - Gomez-Roca,Carlos AU - Michel,Daniela AU - Seroutou,Abdelkader AU - Aslanis,Vassilios AU - Caponigro,Giordano AU - Stuart,Darrin D AU - Moutouh-de Parseval,Laure AU - Demuth,Tim AU - Dummer,Reinhard TI - Phase I Dose-Escalation and -Expansion Study of the BRAF Inhibitor Encorafenib (LGX818) in Metastatic SN - 1557-3265 PY - 2018///0511 KW - Animals KW - Antineoplastic Agents KW - administration & dosage KW - Carbamates KW - Disease Models, Animal KW - Drug Evaluation, Preclinical KW - Drug Monitoring KW - Female KW - Humans KW - Kaplan-Meier Estimate KW - Male KW - Maximum Tolerated Dose KW - Melanoma KW - drug therapy KW - Mice KW - Molecular Targeted Therapy KW - Mutation KW - Neoplasm Staging KW - Protein Kinase Inhibitors KW - Proto-Oncogene Proteins B-raf KW - antagonists & inhibitors KW - Sulfonamides KW - Treatment Outcome KW - Xenograft Model Antitumor Assays N1 - Publication Type: Clinical Trial, Phase I; Journal Article UR - https://doi.org/10.1158/1078-0432.CCR-16-2923 ER -