Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity. [electronic resource]
- Scientific reports 06 2017
- 3182 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
2045-2322
10.1038/s41598-017-03284-w doi
ATP Binding Cassette Transporter, Subfamily B, Member 1--genetics ATP Binding Cassette Transporter, Subfamily G, Member 2--genetics Aldehyde Reductase--antagonists & inhibitors Animals Cardiotoxicity--drug therapy Cell Proliferation Colonic Neoplasms--drug therapy Doxorubicin--administration & dosage Drug Resistance, Neoplasm--genetics Gene Expression Regulation, Neoplastic--drug effects HT29 Cells Humans Imidazolidines--administration & dosage Mice Multidrug Resistance-Associated Proteins--genetics Neoplasm Proteins--genetics Xenograft Model Antitumor Assays