TY - GEN AU - Sagar,Divya AU - Singh,Narendra P AU - Ginwala,Rashida AU - Huang,Xiaofang AU - Philip,Ramila AU - Nagarkatti,Mitzi AU - Nagarkatti,Prakash AU - Neumann,Konstantin AU - Ruland,Jürgen AU - Andrews,Allison M AU - Ramirez,Servio H AU - Khan,Zafar K AU - Jain,Pooja TI - Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity SN - 2045-2322 PY - 2018///1218 KW - Animals KW - Antibodies, Blocking KW - pharmacology KW - Central Nervous System KW - immunology KW - Chemokine CCL2 KW - metabolism KW - Dendritic Cells KW - drug effects KW - Encephalomyelitis, Autoimmune, Experimental KW - diagnosis KW - Endothelium, Vascular KW - Immunity KW - Lectins KW - genetics KW - Lectins, C-Type KW - antagonists & inhibitors KW - Mice KW - Mice, Knockout KW - Models, Biological KW - Myeloid Cells KW - Phenotype KW - Protein Binding KW - Protein Tyrosine Phosphatase, Non-Receptor Type 11 KW - Protein Tyrosine Phosphatase, Non-Receptor Type 6 KW - Receptors, Mitogen KW - Recurrence KW - Severity of Illness Index KW - Signal Transduction KW - Transendothelial and Transepithelial Migration N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/s41598-017-03027-x ER -