TY - GEN AU - Sucker,Antje AU - Zhao,Fang AU - Pieper,Natalia AU - Heeke,Christina AU - Maltaner,Raffaela AU - Stadtler,Nadine AU - Real,Birgit AU - Bielefeld,Nicola AU - Howe,Sebastian AU - Weide,Benjamin AU - Gutzmer,Ralf AU - Utikal,Jochen AU - Loquai,Carmen AU - Gogas,Helen AU - Klein-Hitpass,Ludger AU - Zeschnigk,Michael AU - Westendorf,Astrid M AU - Trilling,Mirko AU - Horn,Susanne AU - Schilling,Bastian AU - Schadendorf,Dirk AU - Griewank,Klaus G AU - Paschen,Annette TI - Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions SN - 2041-1723 PY - 2018///1120 KW - Antigen Presentation KW - genetics KW - Antigens, Neoplasm KW - immunology KW - Antineoplastic Agents, Immunological KW - pharmacology KW - Biopsy KW - Cell Line, Tumor KW - DNA Mutational Analysis KW - Datasets as Topic KW - Drug Resistance, Neoplasm KW - Histocompatibility Antigens Class I KW - Humans KW - Immunotherapy KW - methods KW - Interferon-gamma KW - Janus Kinase 1 KW - Janus Kinase 2 KW - Melanoma KW - drug therapy KW - Mutation KW - Mutation Rate KW - Patient-Specific Modeling KW - Precision Medicine KW - Signal Transduction KW - Skin KW - pathology KW - Skin Neoplasms KW - T-Lymphocytes KW - Treatment Outcome KW - Tumor Escape KW - Whole Genome Sequencing N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/ncomms15440 ER -