Gorman, Jacquelyn A

The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity. [electronic resource] - Nature immunology Jul 2017 - 744-752 p. digital

Publication Type: Journal Article

1529-2916

10.1038/ni.3766 doi


Adolescent
Adult
Animals
Autoimmune Diseases--genetics
Autoimmunity--genetics
Blotting, Southern
Cardiovirus Infections--genetics
Diabetes Mellitus, Experimental--genetics
Diabetes Mellitus, Type 1--genetics
Encephalomyocarditis virus--immunology
Female
Genetic Predisposition to Disease
HEK293 Cells
Humans
Immunoblotting
Interferon Type I--immunology
Interferon-Induced Helicase, IFIH1--genetics
Male
Mice
Middle Aged
Polymorphism, Single Nucleotide
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Virus Diseases--genetics
Young Adult