The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity. [electronic resource]
- Nature immunology Jul 2017
- 744-752 p. digital
Publication Type: Journal Article
1529-2916
10.1038/ni.3766 doi
Adolescent Adult Animals Autoimmune Diseases--genetics Autoimmunity--genetics Blotting, Southern Cardiovirus Infections--genetics Diabetes Mellitus, Experimental--genetics Diabetes Mellitus, Type 1--genetics Encephalomyocarditis virus--immunology Female Genetic Predisposition to Disease HEK293 Cells Humans Immunoblotting Interferon Type I--immunology Interferon-Induced Helicase, IFIH1--genetics Male Mice Middle Aged Polymorphism, Single Nucleotide Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Virus Diseases--genetics Young Adult