PP2A deactivation is a common event in oral cancer and reactivation by FTY720 shows promising therapeutic potential. [electronic resource]
- Journal of cellular physiology Feb 2018
- 1300-1311 p. digital
Publication Type: Journal Article
1097-4652
10.1002/jcp.26001 doi
Adult Aged Aged, 80 and over Antineoplastic Agents--pharmacology Carcinoma, Squamous Cell--drug therapy Cell Line, Tumor Cell Proliferation--drug effects Dose-Response Relationship, Drug Enzyme Activation Enzyme Activators--pharmacology Female Fingolimod Hydrochloride--pharmacology Glycogen Synthase Kinase 3 beta--metabolism Head and Neck Neoplasms--drug therapy Humans Kaplan-Meier Estimate Logistic Models Male Middle Aged Mouth Neoplasms--drug therapy Multivariate Analysis Neoplasm Staging Odds Ratio Phosphorylation Proportional Hazards Models Protein Phosphatase 2--metabolism Risk Factors Signal Transduction--drug effects Squamous Cell Carcinoma of Head and Neck Time Factors Tyrosine