TY - GEN AU - Iovino,Federico AU - Engelen-Lee,Joo-Yeon AU - Brouwer,Matthijs AU - van de Beek,Diederik AU - van der Ende,Arie AU - Valls Seron,Merche AU - Mellroth,Peter AU - Muschiol,Sandra AU - Bergstrand,Jan AU - Widengren,Jerker AU - Henriques-Normark,Birgitta TI - pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion SN - 1540-9538 PY - 2017///0918 KW - Adhesins, Bacterial KW - metabolism KW - Animals KW - Antibodies, Bacterial KW - pharmacology KW - Bacterial Proteins KW - Biopsy KW - Blood-Brain Barrier KW - drug effects KW - Brain KW - Endothelial Cells KW - Fimbriae Proteins KW - Humans KW - Meningitis, Bacterial KW - drug therapy KW - Mice, Inbred C57BL KW - Microscopy KW - Platelet Endothelial Cell Adhesion Molecule-1 KW - Protein Binding KW - Receptors, Polymeric Immunoglobulin KW - Streptococcus pneumoniae KW - isolation & purification KW - Virulence Factors N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1084/jem.20161668 ER -