TY  - GEN
AU  - Zheng,Mengzhu
AU  - Sun,Weiguang
AU  - Gao,Suyu
AU  - Luan,Shanshan
AU  - Li,Dan
AU  - Chen,Renqi
AU  - Zhang,Qian
AU  - Chen,Lixia
AU  - Huang,Jiangeng
AU  - Li,Hua
TI  - Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1
SN  - 1949-2553
PY  - 2018///0406
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemistry
KW  - Binding Sites
KW  - Biomarkers, Tumor
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - drug effects
KW  - Clomiphene
KW  - Enzyme Activation
KW  - Enzyme Inhibitors
KW  - Gene Knockdown Techniques
KW  - Humans
KW  - Inhibitory Concentration 50
KW  - Isocitrate Dehydrogenase
KW  - antagonists & inhibitors
KW  - Male
KW  - Mice
KW  - Models, Molecular
KW  - Molecular Conformation
KW  - Molecular Docking Simulation
KW  - Molecular Dynamics Simulation
KW  - Mutant Proteins
KW  - Protein Binding
KW  - Structure-Activity Relationship
KW  - Substrate Specificity
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.18632/oncotarget.17464
ER  -