Zheng, Mengzhu <br/><br/>
Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1.  [electronic resource] 

 -  Oncotarget  Jul 2017 
 - 44255-44265 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1949-2553 
<br/><br/><label>Standard No.: </label>10.18632/oncotarget.17464  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--chemistry<br/>Binding Sites<br/>Biomarkers, Tumor<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Clomiphene--chemistry<br/>Enzyme Activation--drug effects<br/>Enzyme Inhibitors--chemistry<br/>Gene Knockdown Techniques<br/>Humans<br/>Inhibitory Concentration 50<br/>Isocitrate Dehydrogenase--antagonists & inhibitors<br/>Male<br/>Mice<br/>Models, Molecular<br/>Molecular Conformation<br/>Molecular Docking Simulation<br/>Molecular Dynamics Simulation<br/>Mutant Proteins<br/>Protein Binding<br/>Structure-Activity Relationship<br/>Substrate Specificity<br/>Xenograft Model Antitumor Assays