TY - GEN AU - Sanders,Matthew A AU - Haynes,Brittany AU - Nangia-Makker,Pratima AU - Polin,Lisa A AU - Shekhar,Malathy P TI - Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs SN - 1083-351X PY - 2017///0705 KW - Animals KW - Breast Neoplasms KW - drug therapy KW - Cell Line, Tumor KW - Colonic Neoplasms KW - DNA Repair KW - drug effects KW - DNA Replication KW - DNA, Neoplasm KW - biosynthesis KW - Drug Resistance, Neoplasm KW - Enzyme Inhibitors KW - pharmacology KW - Female KW - Humans KW - Mice KW - Mice, Nude KW - Neoplasm Proteins KW - antagonists & inhibitors KW - Organoplatinum Compounds KW - Oxaliplatin KW - Ubiquitin-Conjugating Enzymes KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article UR - https://doi.org/10.1074/jbc.M117.792192 ER -