TY - GEN AU - Wang,Shuai AU - Xie,Feng AU - Chu,Feng AU - Zhang,Zhengkui AU - Yang,Bing AU - Dai,Tong AU - Gao,Liang AU - Wang,Lin AU - Ling,Li AU - Jia,Junling AU - van Dam,Hans AU - Jin,Jin AU - Zhang,Long AU - Zhou,Fangfang TI - YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKÉ›-mediated phosphorylation SN - 1529-2916 PY - 2017///0828 KW - Adaptor Proteins, Signal Transducing KW - genetics KW - Animals KW - CRISPR-Cas Systems KW - Cell Cycle Proteins KW - Chemokine CCL5 KW - Chemokine CXCL10 KW - Fibroblasts KW - immunology KW - Fluorescent Antibody Technique KW - Gene Editing KW - HEK293 Cells KW - HeLa Cells KW - Humans KW - I-kappa B Kinase KW - metabolism KW - Immunity, Innate KW - Immunoblotting KW - Immunoprecipitation KW - Interferon Regulatory Factor-3 KW - Interferon-beta KW - Lung KW - Lysosomes KW - Macrophages KW - Mice KW - Microscopy, Confocal KW - Phosphoproteins KW - Phosphorylation KW - Protein Serine-Threonine Kinases KW - RAW 264.7 Cells KW - Real-Time Polymerase Chain Reaction KW - Reverse Transcriptase Polymerase Chain Reaction KW - Rhabdoviridae Infections KW - Tumor Suppressor Proteins KW - Vesiculovirus KW - Viral Load KW - YAP-Signaling Proteins N1 - Publication Type: Journal Article UR - https://doi.org/10.1038/ni.3744 ER -