Lan, Linhua Tetramethylpyrazine blocks TFAM degradation and up-regulates mitochondrial DNA copy number by interacting with TFAM. [electronic resource] - Bioscience reports Jun 2017 Publication Type: Journal Article ISSN: 1573-4935 Standard No.: 10.1042/BSR20170319 doi Subjects--Topical Terms: Cell Line, TumorDNA Replication--drug effectsDNA, Mitochondrial--drug effectsDNA-Binding Proteins--geneticsGene Dosage--drug effectsHCT116 CellsHeLa CellsHumansMitochondria--drug effectsMitochondrial Proteins--geneticsPeptide Hydrolases--geneticsPyrazines--pharmacologyTranscription Factors--geneticsTranscription, Genetic--drug effectsUp-Regulation--drug effects