Ye, Yumei <br/><br/>
SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor.  [electronic resource] 

 -  Cardiovascular drugs and therapy  Apr 2017 
 - 119-132 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1573-7241 
<br/><br/><label>Standard No.: </label>10.1007/s10557-017-6725-2  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>AMP-Activated Protein Kinases--metabolism<br/>Adamantane--analogs & derivatives<br/>Animals<br/>Apoptosis--drug effects<br/>Benzhydryl Compounds--pharmacology<br/>CARD Signaling Adaptor Proteins--antagonists & inhibitors<br/>Cells, Cultured<br/>Diabetes Mellitus, Type 2--complications<br/>Diabetic Cardiomyopathies--enzymology<br/>Dipeptides--pharmacology<br/>Dipeptidyl Peptidase 4--metabolism<br/>Dipeptidyl-Peptidase IV Inhibitors--pharmacology<br/>Disease Models, Animal<br/>Drug Therapy, Combination<br/>Fibroblasts--drug effects<br/>Fibrosis<br/>Glucosides--pharmacology<br/>Hypoglycemic Agents--pharmacology<br/>Inflammasomes--antagonists & inhibitors<br/>Inflammation Mediators--metabolism<br/>Kidney Tubules, Proximal--drug effects<br/>Male<br/>Mice, Inbred C57BL<br/>Mice, Obese<br/>Myocytes, Cardiac--drug effects<br/>NLR Family, Pyrin Domain-Containing 3 Protein--antagonists & inhibitors<br/>Signal Transduction--drug effects<br/>Sodium-Glucose Transporter 2--metabolism<br/>Sodium-Glucose Transporter 2 Inhibitors<br/>Stroke Volume--drug effects<br/>Time Factors<br/>Ventricular Function, Left--drug effects