TY  - GEN
AU  - Bender,Aaron M
AU  - Weiner,Rebecca L
AU  - Luscombe,Vincent B
AU  - Cho,Hyekyung P
AU  - Niswender,Colleen M
AU  - Engers,Darren W
AU  - Bridges,Thomas M
AU  - Conn,P Jeffrey
AU  - Lindsley,Craig W
TI  - Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype
SN  - 1464-3405
PY  - 2017///0821
KW  - Animals
KW  - Brain
KW  - metabolism
KW  - Humans
KW  - Inhibitory Concentration 50
KW  - Muscarinic Antagonists
KW  - chemical synthesis
KW  - Protein Binding
KW  - Pyrimidines
KW  - Rats
KW  - Receptor, Muscarinic M4
KW  - antagonists & inhibitors
KW  - Receptors, Muscarinic
KW  - chemistry
KW  - Recombinant Proteins
KW  - biosynthesis
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.bmcl.2017.04.009
ER  -