Bender, Aaron M <br/><br/>
Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  06 2017 
 - 2479-2483 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2017.04.009  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Brain--metabolism<br/>Humans<br/>Inhibitory Concentration 50<br/>Muscarinic Antagonists--chemical synthesis<br/>Protein Binding<br/>Pyrimidines--chemical synthesis<br/>Rats<br/>Receptor, Muscarinic M4--antagonists & inhibitors<br/>Receptors, Muscarinic--chemistry<br/>Recombinant Proteins--biosynthesis<br/>Structure-Activity Relationship