Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo. [electronic resource]
- The FEBS journal 06 2017
- 1657-1671 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1742-4658
10.1111/febs.14066 doi
ADAM Proteins--metabolism ADAM12 Protein--metabolism Amino Acid Sequence Animals Antibodies, Neutralizing--pharmacology Apoptosis Regulatory Proteins--metabolism Cell Adhesion--drug effects Crotalid Venoms--metabolism Drug Resistance Fibrinogen--metabolism Fibronectins--metabolism HeLa Cells Hemorrhage--chemically induced Human Umbilical Vein Endothelial Cells Humans Hydrophobic and Hydrophilic Interactions Low Density Lipoprotein Receptor-Related Protein-5--chemistry Low Density Lipoprotein Receptor-Related Protein-6--chemistry Male Membrane Proteins--metabolism Metalloendopeptidases--metabolism Mice Models, Molecular Molecular Docking Simulation Protein Domains Protein Structure, Secondary--drug effects Recombinant Proteins--metabolism Sequence Alignment Sequence Homology, Amino Acid Species Specificity Vertebrates--metabolism Wnt Signaling Pathway--drug effects