Paparin, Jean-Laurent <br/><br/>
Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  06 2017 
 - 2634-2640 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2017.01.017  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Allosteric Regulation<br/>Animals<br/>Antiviral Agents--chemical synthesis<br/>Binding Sites<br/>Crystallography, X-Ray<br/>Genotype<br/>Half-Life<br/>Haplorhini<br/>Hepacivirus--enzymology<br/>Humans<br/>Lactams--chemistry<br/>Mice<br/>Molecular Dynamics Simulation<br/>Organophosphorus Compounds--chemistry<br/>Protein Structure, Tertiary<br/>Rats<br/>Structure-Activity Relationship<br/>Sulfonamides--chemistry<br/>Viral Nonstructural Proteins--antagonists & inhibitors<br/>Virus Replication--drug effects