TY  - GEN
AU  - Alizadeh,Javad
AU  - Zeki,Amir A
AU  - Mirzaei,Nima
AU  - Tewary,Sandipan
AU  - Rezaei Moghadam,Adel
AU  - Glogowska,Aleksandra
AU  - Nagakannan,Pandian
AU  - Eftekharpour,Eftekhar
AU  - Wiechec,Emilia
AU  - Gordon,Joseph W
AU  - Xu,Fred Y
AU  - Field,Jared T
AU  - Yoneda,Ken Y
AU  - Kenyon,Nicholas J
AU  - Hashemi,Mohammad
AU  - Hatch,Grant M
AU  - Hombach-Klonisch,Sabine
AU  - Klonisch,Thomas
AU  - Ghavami,Saeid
TI  - Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells
SN  - 2045-2322
PY  - 2018///1112
KW  - Alkyl and Aryl Transferases
KW  - metabolism
KW  - Apoptosis
KW  - drug effects
KW  - Cell Death
KW  - Cell Line, Tumor
KW  - Cell Membrane
KW  - Cholesterol
KW  - Dose-Response Relationship, Drug
KW  - Farnesyltranstransferase
KW  - Humans
KW  - Hydroxymethylglutaryl-CoA Reductase Inhibitors
KW  - pharmacology
KW  - Metabolic Networks and Pathways
KW  - Mevalonic Acid
KW  - Protein Transport
KW  - Signal Transduction
KW  - Simvastatin
KW  - Terpenes
KW  - rho GTP-Binding Proteins
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/srep44841
ER  -