TY - GEN AU - Gopal,Pooja AU - Tasneen,Rokeya AU - Yee,Michelle AU - Lanoix,Jean-Philippe AU - Sarathy,Jansy AU - Rasic,George AU - Li,Liping AU - Dartois,Véronique AU - Nuermberger,Eric AU - Dick,Thomas TI - In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1 SN - 2373-8227 PY - 2017///1129 KW - Animals KW - Antitubercular Agents KW - pharmacology KW - Bacterial Proteins KW - genetics KW - Carboxy-Lyases KW - Culture Media KW - Disease Models, Animal KW - Drug Resistance, Bacterial KW - Female KW - Gene Expression KW - Genome, Bacterial KW - Heat-Shock Proteins KW - Humans KW - Mice KW - Mice, Inbred BALB C KW - Microbial Sensitivity Tests KW - Mutation, Missense KW - Mycobacterium tuberculosis KW - drug effects KW - Polyketide Synthases KW - Pyrazinamide KW - analogs & derivatives KW - Selection, Genetic KW - Sequence Analysis, DNA KW - Tuberculosis KW - drug therapy N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1021/acsinfecdis.7b00017 ER -