TY  - GEN
AU  - Kazi,Julhash U
AU  - Chougule,Rohit A
AU  - Li,Tianfeng
AU  - Su,Xianwei
AU  - Moharram,Sausan A
AU  - Rupar,Kaja
AU  - Marhäll,Alissa
AU  - Gazi,Mohiuddin
AU  - Sun,Jianmin
AU  - Zhao,Hui
AU  - Rönnstrand,Lars
TI  - Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD
SN  - 1420-9071
PY  - 2017///0828
KW  - Animals
KW  - Apoptosis
KW  - Cell Line
KW  - Cell Proliferation
KW  - Cell Transformation, Neoplastic
KW  - metabolism
KW  - Down-Regulation
KW  - Enzyme Activation
KW  - Extracellular Signal-Regulated MAP Kinases
KW  - Gene Duplication
KW  - Humans
KW  - Male
KW  - Mice, Inbred BALB C
KW  - Mutant Proteins
KW  - Mutation
KW  - genetics
KW  - Myeloid Cells
KW  - Oncogenes
KW  - Phosphorylation
KW  - Protein Stability
KW  - Protein Tyrosine Phosphatase, Non-Receptor Type 11
KW  - Proteolysis
KW  - Signal Transduction
KW  - Tyrosine
KW  - Ubiquitination
KW  - fms-Like Tyrosine Kinase 3
KW  - chemistry
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1007/s00018-017-2494-0
ER  -