TY  - GEN
AU  - Maier,Christiane
AU  - Ramming,Andreas
AU  - Bergmann,Christina
AU  - Weinkam,Rita
AU  - Kittan,Nicolai
AU  - Schett,Georg
AU  - Distler,Jörg H W
AU  - Beyer,Christian
TI  - Inhibition of phosphodiesterase 4 (PDE4) reduces dermal fibrosis by interfering with the release of interleukin-6 from M2 macrophages
SN  - 1468-2060
PY  - 2017///0814
KW  - Animals
KW  - Bleomycin
KW  - Cell Differentiation
KW  - drug effects
KW  - Collagen
KW  - metabolism
KW  - Cyclic Nucleotide Phosphodiesterases, Type 4
KW  - Cytokines
KW  - genetics
KW  - DNA Topoisomerases, Type I
KW  - immunology
KW  - Disease Models, Animal
KW  - Fibroblasts
KW  - Fibrosis
KW  - Gene Expression
KW  - Graft vs Host Disease
KW  - complications
KW  - Humans
KW  - Interleukin-13
KW  - Interleukin-6
KW  - Macrophages
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Mice, Inbred C57BL
KW  - Phosphodiesterase 4 Inhibitors
KW  - pharmacology
KW  - RNA, Messenger
KW  - Rolipram
KW  - Scleroderma, Systemic
KW  - drug therapy
KW  - Skin
KW  - Thalidomide
KW  - analogs & derivatives
KW  - Transforming Growth Factor beta1
KW  - Transforming Growth Factor beta2
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1136/annrheumdis-2016-210189
ER  -