Maier, Christiane <br/><br/>
Inhibition of phosphodiesterase 4 (PDE4) reduces dermal fibrosis by interfering with the release of interleukin-6 from M2 macrophages.  [electronic resource] 

 -  Annals of the rheumatic diseases  Jun 2017 
 - 1133-1141 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1468-2060 
<br/><br/><label>Standard No.: </label>10.1136/annrheumdis-2016-210189  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Bleomycin<br/>Cell Differentiation--drug effects<br/>Collagen--metabolism<br/>Cyclic Nucleotide Phosphodiesterases, Type 4--metabolism<br/>Cytokines--genetics<br/>DNA Topoisomerases, Type I--immunology<br/>Disease Models, Animal<br/>Fibroblasts--drug effects<br/>Fibrosis<br/>Gene Expression--drug effects<br/>Graft vs Host Disease--complications<br/>Humans<br/>Interleukin-13--genetics<br/>Interleukin-6--genetics<br/>Macrophages--drug effects<br/>Mice<br/>Mice, Inbred BALB C<br/>Mice, Inbred C57BL<br/>Phosphodiesterase 4 Inhibitors--pharmacology<br/>RNA, Messenger--metabolism<br/>Rolipram--pharmacology<br/>Scleroderma, Systemic--drug therapy<br/>Skin--drug effects<br/>Thalidomide--analogs & derivatives<br/>Transforming Growth Factor beta1--genetics<br/>Transforming Growth Factor beta2--genetics