TY  - GEN
AU  - Ju,H-Q
AU  - Zhan,G
AU  - Huang,A
AU  - Sun,Y
AU  - Wen,S
AU  - Yang,J
AU  - Lu,W-H
AU  - Xu,R-H
AU  - Li,J
AU  - Li,Y
AU  - Garcia-Manero,G
AU  - Huang,P
AU  - Hu,Y
TI  - ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition
SN  - 1476-5551
PY  - 2017///1024
KW  - Adenosine Triphosphate
KW  - metabolism
KW  - Animals
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Cell Line
KW  - Cell Transformation, Neoplastic
KW  - Deoxyglucose
KW  - Glycolysis
KW  - drug effects
KW  - Hematopoietic Stem Cells
KW  - cytology
KW  - Hexokinase
KW  - biosynthesis
KW  - Humans
KW  - Hydrocarbons, Brominated
KW  - Leukemia, Experimental
KW  - drug therapy
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Microsatellite Repeats
KW  - Mitochondria
KW  - enzymology
KW  - Molecular Targeted Therapy
KW  - Neoplasm Proteins
KW  - genetics
KW  - Niacinamide
KW  - analogs & derivatives
KW  - Phenylurea Compounds
KW  - Propionates
KW  - Proto-Oncogene Proteins c-akt
KW  - Sorafenib
KW  - fms-Like Tyrosine Kinase 3
KW  - antagonists & inhibitors
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1038/leu.2017.45
ER  -