TY - GEN AU - Moon,Su-Jin AU - Kim,Eun-Kyung AU - Jhun,Joo Yeon AU - Lee,Hee Jin AU - Lee,Weon Sun AU - Park,Sang-Hi AU - Cho,Mi-La AU - Min,Jun-Ki TI - The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1 SN - 1479-5876 PY - 2017///1020 KW - Aniline Compounds KW - pharmacology KW - Animals KW - Anti-Inflammatory Agents KW - Arthritis, Experimental KW - complications KW - Arthritis, Rheumatoid KW - drug therapy KW - Cell Differentiation KW - drug effects KW - Crotonates KW - Forkhead Transcription Factors KW - metabolism KW - Heme Oxygenase-1 KW - Humans KW - Hydroxybutyrates KW - Inflammation KW - Isoxazoles KW - Jurkat Cells KW - Leflunomide KW - Mice, Inbred BALB C KW - Mice, Inbred C57BL KW - NF-E2-Related Factor 2 KW - Nitric Oxide Synthase Type II KW - Nitriles KW - Oxidative Stress KW - Signal Transduction KW - Spleen KW - pathology KW - Th17 Cells KW - cytology KW - Toluidines KW - Tyrosine KW - analogs & derivatives N1 - Publication Type: Journal Article UR - https://doi.org/10.1186/s12967-017-1131-x ER -