TY - GEN AU - Bellini,Dom AU - Horrell,Sam AU - Hutchin,Andrew AU - Phippen,Curtis W AU - Strange,Richard W AU - Cai,Yuming AU - Wagner,Armin AU - Webb,Jeremy S AU - Tews,Ivo AU - Walsh,Martin A TI - Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases SN - 2045-2322 PY - 2018///1030 KW - Bacterial Proteins KW - chemistry KW - Biocatalysis KW - Catalytic Domain KW - Cations, Divalent KW - Cloning, Molecular KW - Crystallography, X-Ray KW - Cyclic GMP KW - analogs & derivatives KW - Escherichia coli KW - genetics KW - Gene Expression KW - Genetic Vectors KW - Hydrolysis KW - Kinetics KW - Magnesium KW - Manganese KW - Models, Molecular KW - Phosphoric Diester Hydrolases KW - Protein Binding KW - Protein Conformation, alpha-Helical KW - Protein Conformation, beta-Strand KW - Protein Interaction Domains and Motifs KW - Protein Multimerization KW - Pseudomonas aeruginosa KW - Recombinant Proteins KW - Substrate Specificity N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1038/srep42166 ER -