TY - GEN AU - Thorarensen,Atli AU - Dowty,Martin E AU - Banker,Mary Ellen AU - Juba,Brian AU - Jussif,Jason AU - Lin,Tsung AU - Vincent,Fabien AU - Czerwinski,Robert M AU - Casimiro-Garcia,Agustin AU - Unwalla,Ray AU - Trujillo,John I AU - Liang,Sidney AU - Balbo,Paul AU - Che,Ye AU - Gilbert,Adam M AU - Brown,Matthew F AU - Hayward,Matthew AU - Montgomery,Justin AU - Leung,Louis AU - Yang,Xin AU - Soucy,Sarah AU - Hegen,Martin AU - Coe,Jotham AU - Langille,Jonathan AU - Vajdos,Felix AU - Chrencik,Jill AU - Telliez,Jean-Baptiste TI - Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans SN - 1520-4804 PY - 2017///0807 KW - Administration, Oral KW - Drug Design KW - Humans KW - Janus Kinase 3 KW - antagonists & inhibitors KW - Protein Kinase Inhibitors KW - administration & dosage KW - Pyrimidines KW - Pyrroles KW - Signal Transduction KW - drug effects N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S UR - https://doi.org/10.1021/acs.jmedchem.6b01694 ER -