TY  - GEN
AU  - Einolf,Heidi J
AU  - Zhou,Jocelyn
AU  - Won,Christina
AU  - Wang,Lai
AU  - Rebello,Sam
TI  - A Physiologically-Based Pharmacokinetic Modeling Approach To Predict Drug-Drug Interactions of Sonidegib (LDE225) with Perpetrators of CYP3A in Cancer Patients
SN  - 1521-009X
PY  - 2017///1229
KW  - Adult
KW  - Biphenyl Compounds
KW  - administration & dosage
KW  - Computer Simulation
KW  - Cytochrome P-450 CYP3A
KW  - metabolism
KW  - Cytochrome P-450 CYP3A Inducers
KW  - Cytochrome P-450 CYP3A Inhibitors
KW  - Drug Interactions
KW  - Female
KW  - Healthy Volunteers
KW  - Humans
KW  - Ketoconazole
KW  - Male
KW  - Metabolic Clearance Rate
KW  - Middle Aged
KW  - Models, Biological
KW  - Neoplasms
KW  - drug therapy
KW  - Pyridines
KW  - Rifampin
KW  - Smoothened Receptor
KW  - antagonists & inhibitors
KW  - Time Factors
KW  - Young Adult
N1  - Publication Type: Journal Article; Randomized Controlled Trial
UR  - https://doi.org/10.1124/dmd.116.073585
ER  -