Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway. [electronic resource]
- Nature communications 01 2017
- 13700 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
2041-1723
10.1038/ncomms13700 doi
ADP Ribose Transferases Animals Bone Density Botulinum Toxins Female GTP-Binding Protein alpha Subunits, G12-G13--genetics Gene Expression Regulation--drug effects Gene Silencing Glycogen Synthase Kinase 3 beta--genetics Heterocyclic Compounds, 3-Ring--pharmacology Humans Leukocytes, Mononuclear--physiology Lipoproteins--toxicity Macrophage Colony-Stimulating Factor Male Mice NFATC Transcription Factors--genetics Osteogenesis--physiology Ovariectomy Proto-Oncogene Proteins c-akt--genetics RANK Ligand Signal Transduction--physiology