TY - GEN AU - Milewicz,Dianna M AU - Prakash,Siddharth K AU - Ramirez,Francesco TI - Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models SN - 1545-326X PY - 2018///0101 KW - Aortic Dissection KW - genetics KW - Angiotensin II KW - metabolism KW - Animals KW - Antihypertensive Agents KW - therapeutic use KW - Aortic Aneurysm, Thoracic KW - Disease Models, Animal KW - Genetic Predisposition to Disease KW - Humans KW - Losartan KW - Marfan Syndrome KW - Mechanoreceptors KW - Mice KW - Muscle, Smooth, Vascular KW - physiopathology KW - Signal Transduction KW - Transforming Growth Factor beta N1 - Publication Type: Journal Article; Review UR - https://doi.org/10.1146/annurev-med-100415-022956 ER -