Kang, Seong Su

α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America 01 2017 - 1183-1188 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1091-6490

10.1073/pnas.1618627114 doi


1-Methyl-4-phenylpyridinium--toxicity
Adenylate Kinase--metabolism
Aged
Aged, 80 and over
Animals
Cell Death
Dopaminergic Neurons--metabolism
Enzyme Activation
GTP Phosphohydrolases--deficiency
GTP-Binding Proteins--chemistry
GTPase-Activating Proteins--chemistry
Humans
Lewy Bodies--metabolism
MPTP Poisoning--metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Nerve Tissue Proteins--deficiency
Phosphorylation
Pleckstrin Homology Domains
Protein Aggregation, Pathological
Protein Binding
Protein Interaction Mapping
Protein Processing, Post-Translational
Proto-Oncogene Proteins c-fyn--deficiency
alpha-Synuclein--metabolism