α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America 01 2017
- 1183-1188 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.1618627114 doi
1-Methyl-4-phenylpyridinium--toxicity Adenylate Kinase--metabolism Aged Aged, 80 and over Animals Cell Death Dopaminergic Neurons--metabolism Enzyme Activation GTP Phosphohydrolases--deficiency GTP-Binding Proteins--chemistry GTPase-Activating Proteins--chemistry Humans Lewy Bodies--metabolism MPTP Poisoning--metabolism Mice Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins--deficiency Phosphorylation Pleckstrin Homology Domains Protein Aggregation, Pathological Protein Binding Protein Interaction Mapping Protein Processing, Post-Translational Proto-Oncogene Proteins c-fyn--deficiency alpha-Synuclein--metabolism