The PI3K/mTOR dual inhibitor BEZ235 suppresses proliferation and migration and reverses multidrug resistance in acute myeloid leukemia. [electronic resource]
- Acta pharmacologica Sinica Mar 2017
- 382-391 p. digital
Publication Type: Journal Article
1745-7254
10.1038/aps.2016.121 doi
ATP Binding Cassette Transporter, Subfamily B--metabolism Adaptor Proteins, Signal Transducing--metabolism Antineoplastic Agents--pharmacology Cell Line, Tumor--drug effects Cell Movement--drug effects Cell Proliferation--drug effects Drug Resistance, Multiple--drug effects Drug Resistance, Neoplasm--drug effects Endothelin-1--metabolism Humans Imidazoles--pharmacology Leukemia, Myeloid, Acute--drug therapy MicroRNAs--metabolism Phosphoinositide-3 Kinase Inhibitors Protein Kinase Inhibitors--pharmacology Quinolines--pharmacology TOR Serine-Threonine Kinases--antagonists & inhibitors