TY - GEN AU - Zhen,Mao-Chuan AU - Wang,Fu-Qiang AU - Wu,Shao-Feng AU - Zhao,Yi-Lin AU - Liu,Ping-Guo AU - Yin,Zhen-Yu TI - Identification of mTOR as a primary resistance factor of the IAP antagonist AT406 in hepatocellular carcinoma cells SN - 1949-2553 PY - 2018///0222 KW - Acetates KW - pharmacology KW - Animals KW - Antineoplastic Agents KW - Antineoplastic Combined Chemotherapy Protocols KW - Apoptosis KW - drug effects KW - Azocines KW - Benzhydryl Compounds KW - Benzopyrans KW - Carcinoma, Hepatocellular KW - drug therapy KW - Dose-Response Relationship, Drug KW - Drug Resistance, Neoplasm KW - Female KW - Hep G2 Cells KW - Humans KW - Imidazoles KW - Inhibitor of Apoptosis Proteins KW - antagonists & inhibitors KW - Liver Neoplasms KW - Mice, Nude KW - Mutation KW - Myeloid Cell Leukemia Sequence 1 Protein KW - genetics KW - Protein Kinase Inhibitors KW - Protein Stability KW - Proteolysis KW - RNA Interference KW - Ribosomal Protein S6 Kinases, 70-kDa KW - Signal Transduction KW - TOR Serine-Threonine Kinases KW - Time Factors KW - Transfection KW - Triazines KW - Tumor Burden KW - Ubiquitin-Protein Ligases KW - X-Linked Inhibitor of Apoptosis Protein KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article UR - https://doi.org/10.18632/oncotarget.14326 ER -