TY  - GEN
AU  - Scharf,Nathan T
AU  - Molodtsov,Vadim
AU  - Kontos,Arrin
AU  - Murakami,Katsuhiko S
AU  - Garcia,George A
TI  - Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening
SN  - 2472-5560
PY  - 2018///1231
KW  - Antitubercular Agents
KW  - pharmacology
KW  - Aptamers, Nucleotide
KW  - genetics
KW  - Bacterial Proteins
KW  - antagonists & inhibitors
KW  - Biological Assay
KW  - DNA-Directed RNA Polymerases
KW  - Drug Discovery
KW  - Drug Resistance, Bacterial
KW  - drug effects
KW  - Escherichia coli
KW  - Extensively Drug-Resistant Tuberculosis
KW  - drug therapy
KW  - Gene Expression
KW  - High-Throughput Screening Assays
KW  - Humans
KW  - Microbial Sensitivity Tests
KW  - Mutation
KW  - Mycobacterium tuberculosis
KW  - Plasmids
KW  - chemistry
KW  - Rifampin
KW  - Rifamycins
KW  - Small Molecule Libraries
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1177/2472555216679994
ER  -