Scharf, Nathan T <br/><br/>
Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening.  [electronic resource] 

 -  SLAS discovery : advancing life sciences R & D  03 2017 
 - 287-297 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>2472-5560 
<br/><br/><label>Standard No.: </label>10.1177/2472555216679994  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antitubercular Agents--pharmacology<br/>Aptamers, Nucleotide--genetics<br/>Bacterial Proteins--antagonists & inhibitors<br/>Biological Assay<br/>DNA-Directed RNA Polymerases--antagonists & inhibitors<br/>Drug Discovery<br/>Drug Resistance, Bacterial--drug effects<br/>Escherichia coli--drug effects<br/>Extensively Drug-Resistant Tuberculosis--drug therapy<br/>Gene Expression<br/>High-Throughput Screening Assays<br/>Humans<br/>Microbial Sensitivity Tests<br/>Mutation<br/>Mycobacterium tuberculosis--drug effects<br/>Plasmids--chemistry<br/>Rifampin--pharmacology<br/>Rifamycins--pharmacology<br/>Small Molecule Libraries--chemistry<br/>Structure-Activity Relationship