Song, Doona <br/><br/>
Improving potency and metabolic stability by introducing an alkenyl linker to pyridine-based histone deacetylase inhibitors for orally available RUNX3 modulators.  [electronic resource] 

 -  European journal of medicinal chemistry  Jan 2017 
 - 997-1010 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1768-3254 
<br/><br/><label>Standard No.: </label>10.1016/j.ejmech.2016.11.055  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Acetylation<br/>Administration, Oral<br/>Animals<br/>Biological Availability<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Core Binding Factor Alpha 3 Subunit--chemistry<br/>Drug Stability<br/>Female<br/>Histone Deacetylase Inhibitors--chemistry<br/>Histone Deacetylases--metabolism<br/>Humans<br/>Mice<br/>Microsomes--metabolism<br/>Protein Stability--drug effects<br/>Pyridines--chemistry<br/>Structure-Activity Relationship<br/>Xenograft Model Antitumor Assays