Jones, Stuart <br/><br/>
Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.  [electronic resource] 

 -  Journal of medicinal chemistry  12 2016 
 - 11120-11137 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/acs.jmedchem.6b01320  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Allosteric Regulation--drug effects<br/>Cell Differentiation--drug effects<br/>Dose-Response Relationship, Drug<br/>Drug Discovery<br/>Enzyme Inhibitors--chemistry<br/>Humans<br/>Isocitrate Dehydrogenase--antagonists & inhibitors<br/>Leukemia, Myeloid, Acute--enzymology<br/>Models, Molecular<br/>Molecular Structure<br/>Structure-Activity Relationship<br/>Tumor Cells, Cultured