TY - GEN AU - Wu,Lianfeng AU - Zhou,Ben AU - Oshiro-Rapley,Noriko AU - Li,Man AU - Paulo,Joao A AU - Webster,Christopher M AU - Mou,Fan AU - Kacergis,Michael C AU - Talkowski,Michael E AU - Carr,Christopher E AU - Gygi,Steven P AU - Zheng,Bin AU - Soukas,Alexander A TI - An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer SN - 1097-4172 PY - 2017///0509 KW - Acyl-CoA Dehydrogenase KW - genetics KW - Aging KW - Animals KW - Body Size KW - Caenorhabditis elegans KW - growth & development KW - Caenorhabditis elegans Proteins KW - Cell Line, Tumor KW - DNA-Binding Proteins KW - metabolism KW - Humans KW - Longevity KW - Mechanistic Target of Rapamycin Complex 1 KW - Metformin KW - pharmacology KW - Mitochondria KW - Monomeric GTP-Binding Proteins KW - Multiprotein Complexes KW - Neoplasms KW - drug therapy KW - Nuclear Pore KW - Oxidative Phosphorylation KW - Signal Transduction KW - drug effects KW - TOR Serine-Threonine Kinases KW - Transcription Factors N1 - Publication Type: Journal Article UR - https://doi.org/10.1016/j.cell.2016.11.055 ER -