The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo. [electronic resource]
- Toxicology in vitro : an international journal published in association with BIBRA Apr 2017
- 26-33 p. digital
Publication Type: Journal Article
1879-3177
10.1016/j.tiv.2016.12.002 doi
ATP Binding Cassette Transporter, Subfamily B, Member 1--antagonists & inhibitors Adult Aged Aged, 80 and over Colon--metabolism Cyclosporins--pharmacology Cytochrome P-450 CYP3A--metabolism Cytochrome P-450 CYP3A Inhibitors--pharmacology Drug Interactions Female Humans Ileum--metabolism In Vitro Techniques Isoquinolines--pharmacology Jejunum--metabolism Ketoconazole--pharmacology Male Middle Aged Quinazolines--pharmacology Quinidine--analogs & derivatives Verapamil--pharmacology