TY - GEN AU - Miller,Miles A AU - Sullivan,Ryan J AU - Lauffenburger,Douglas A TI - Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer SN - 1557-3265 PY - 2018///0305 KW - ADAM10 Protein KW - antagonists & inhibitors KW - ADAM17 Protein KW - Antineoplastic Agents KW - metabolism KW - Body Fluids KW - chemistry KW - Drug Design KW - Drug Resistance, Neoplasm KW - physiology KW - Enzyme Activation KW - Humans KW - Immunotherapy KW - Macrophages KW - Molecular Targeted Therapy KW - Neoplasm Proteins KW - analysis KW - Neoplasms KW - drug therapy KW - Peptide Fragments KW - Protein Domains KW - Protein Kinase Inhibitors KW - pharmacology KW - Proteolysis KW - drug effects KW - Receptors, Cell Surface KW - Substrate Specificity KW - Tissue Inhibitor of Metalloproteinases KW - Tumor Microenvironment N1 - Publication Type: Journal Article; Review UR - https://doi.org/10.1158/1078-0432.CCR-16-0869 ER -