TY - GEN AU - Liu,Feiyan AU - Li,Xia AU - Lu,Chunwan AU - Bai,Aiping AU - Bielawski,Jacek AU - Bielawska,Alicja AU - Marshall,Brendan AU - Schoenlein,Patricia V AU - Lebedyeva,Iryna O AU - Liu,Kebin TI - Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells SN - 1949-2553 PY - 2018///0221 KW - Acid Ceramidase KW - antagonists & inhibitors KW - Animals KW - Antineoplastic Agents KW - pharmacology KW - Autophagy KW - drug effects KW - Cathepsin B KW - metabolism KW - Cathepsin D KW - Cell Line, Tumor KW - Ceramides KW - Dose-Response Relationship, Drug KW - Endoplasmic Reticulum Stress KW - Enzyme Activation KW - Enzyme Inhibitors KW - Lysosomes KW - Mice, Inbred BALB C KW - Myeloid-Derived Suppressor Cells KW - Sarcoma KW - drug therapy KW - Signal Transduction KW - Time Factors N1 - Publication Type: Journal Article UR - https://doi.org/10.18632/oncotarget.13438 ER -