Liu, Feiyan

Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells. [electronic resource] - Oncotarget Dec 2016 - 83907-83925 p. digital

Publication Type: Journal Article

1949-2553

10.18632/oncotarget.13438 doi


Acid Ceramidase--antagonists & inhibitors
Animals
Antineoplastic Agents--pharmacology
Autophagy--drug effects
Cathepsin B--metabolism
Cathepsin D--metabolism
Cell Line, Tumor
Ceramides--metabolism
Dose-Response Relationship, Drug
Endoplasmic Reticulum Stress--drug effects
Enzyme Activation
Enzyme Inhibitors--pharmacology
Lysosomes--drug effects
Mice, Inbred BALB C
Myeloid-Derived Suppressor Cells--drug effects
Sarcoma--drug therapy
Signal Transduction--drug effects
Time Factors