Liu, Feiyan Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells. [electronic resource] - Oncotarget Dec 2016 - 83907-83925 p. digital Publication Type: Journal Article ISSN: 1949-2553 Standard No.: 10.18632/oncotarget.13438 doi Subjects--Topical Terms: Acid Ceramidase--antagonists & inhibitorsAnimalsAntineoplastic Agents--pharmacologyAutophagy--drug effectsCathepsin B--metabolismCathepsin D--metabolismCell Line, TumorCeramides--metabolismDose-Response Relationship, DrugEndoplasmic Reticulum Stress--drug effectsEnzyme ActivationEnzyme Inhibitors--pharmacologyLysosomes--drug effectsMice, Inbred BALB CMyeloid-Derived Suppressor Cells--drug effectsSarcoma--drug therapySignal Transduction--drug effectsTime Factors