DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling. [electronic resource]
- Nature medicine 12 2016
- 1488-1495 p. digital
Publication Type: Journal Article
1546-170X
10.1038/nm.4210 doi
Animals Anthracyclines--therapeutic use Antineoplastic Agents--therapeutic use Cell Line, Tumor Cell Proliferation--genetics Cell Survival Chromatin Assembly and Disassembly--genetics DNA (Cytosine-5-)-Methyltransferases--genetics DNA Methyltransferase 3A Daunorubicin--therapeutic use Drug Resistance, Neoplasm--genetics Hematopoietic Stem Cells Humans Immunoblotting Immunoprecipitation Leukemia, Myeloid, Acute--drug therapy Mass Spectrometry Mice Mutation Nuclear Proteins--genetics Nucleophosmin Nucleosomes--metabolism fms-Like Tyrosine Kinase 3--genetics