TY - GEN AU - Marino Gammazza,Antonella AU - Campanella,Claudia AU - Barone,Rosario AU - Caruso Bavisotto,Celeste AU - Gorska,Magdalena AU - Wozniak,Michal AU - Carini,Francesco AU - Cappello,Francesco AU - D'Anneo,Antonella AU - Lauricella,Marianna AU - Zummo,Giovanni AU - Conway de Macario,Everly AU - Macario,Alberto J L AU - Di Felice,Valentina TI - Doxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence SN - 1872-7980 PY - 2017///0808 KW - Acetylation KW - Antibiotics, Antineoplastic KW - pharmacology KW - Apoptosis KW - drug effects KW - Carcinoma, Mucoepidermoid KW - drug therapy KW - Cell Line, Tumor KW - Cell Proliferation KW - Cell Survival KW - Cellular Senescence KW - Chaperonin 60 KW - genetics KW - Chaperonins KW - metabolism KW - Cyclin-Dependent Kinase Inhibitor p21 KW - Dose-Response Relationship, Drug KW - Doxorubicin KW - G2 Phase Cell Cycle Checkpoints KW - Histones KW - Humans KW - Lung Neoplasms KW - Mitochondrial Proteins KW - Protein Binding KW - Protein Processing, Post-Translational KW - Proteolysis KW - Signal Transduction KW - Tumor Suppressor Protein p53 KW - Ubiquitination N1 - Publication Type: Journal Article UR - https://doi.org/10.1016/j.canlet.2016.10.045 ER -