Oviedo, Alberto <br/><br/>
Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke.  [electronic resource] 

 -  Regulatory toxicology and pharmacology : RTP  Nov 2016 
 - S93-S122 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article 
<br/><br/><label>ISSN: </label>1096-0295 
<br/><br/><label>Standard No.: </label>10.1016/j.yrtph.2016.11.004  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aerosols<br/>Animals<br/>Biomarkers--blood<br/>Computational Biology<br/>Consumer Product Safety<br/>Dose-Response Relationship, Drug<br/>Electronic Nicotine Delivery Systems--adverse effects<br/>Equipment Design<br/>Female<br/>Gene Expression Profiling<br/>Gene Expression Regulation--drug effects<br/>Genetic Markers<br/>Genomics<br/>Harm Reduction<br/>Hot Temperature<br/>Humans<br/>Inhalation Exposure--adverse effects<br/>Lung--drug effects<br/>Male<br/>Menthol--analysis<br/>Nasal Mucosa--drug effects<br/>Rats, Sprague-Dawley<br/>Risk Assessment<br/>Smoke--adverse effects<br/>Smoking--adverse effects<br/>Time Factors<br/>Tobacco Industry<br/>Tobacco Products--analysis<br/>Toxicity Tests--methods<br/>Toxicogenetics<br/>Transcriptome--drug effects