TY  - GEN
AU  - Kottakis,Filippos
AU  - Nicolay,Brandon N
AU  - Roumane,Ahlima
AU  - Karnik,Rahul
AU  - Gu,Hongcang
AU  - Nagle,Julia M
AU  - Boukhali,Myriam
AU  - Hayward,Michele C
AU  - Li,Yvonne Y
AU  - Chen,Ting
AU  - Liesa,Marc
AU  - Hammerman,Peter S
AU  - Wong,Kwok Kin
AU  - Hayes,D Neil
AU  - Shirihai,Orian S
AU  - Dyson,Nicholas J
AU  - Haas,Wilhelm
AU  - Meissner,Alexander
AU  - Bardeesy,Nabeel
TI  - LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
SN  - 1476-4687
PY  - 2017///0321
KW  - AMP-Activated Protein Kinase Kinases
KW  - AMP-Activated Protein Kinases
KW  - Animals
KW  - Cell Culture Techniques
KW  - Cell Line, Tumor
KW  - Cell Transformation, Neoplastic
KW  - Chromatin
KW  - genetics
KW  - DNA (Cytosine-5-)-Methyltransferases
KW  - metabolism
KW  - DNA Methylation
KW  - drug effects
KW  - Enzyme Inhibitors
KW  - pharmacology
KW  - Epithelial Cells
KW  - Gene Silencing
KW  - Genes, Tumor Suppressor
KW  - Glycine
KW  - Glycolysis
KW  - Humans
KW  - Mice
KW  - Pancreatic Ducts
KW  - cytology
KW  - Protein Serine-Threonine Kinases
KW  - deficiency
KW  - Proto-Oncogene Proteins p21(ras)
KW  - Retroelements
KW  - S-Adenosylmethionine
KW  - Serine
KW  - biosynthesis
KW  - TOR Serine-Threonine Kinases
KW  - Transaminases
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/nature20132
ER  -