TY - GEN AU - Mahmoud,Tamer I AU - Wang,Jingya AU - Karnell,Jodi L AU - Wang,Qiming AU - Wang,Shu AU - Naiman,Brian AU - Gross,Phillip AU - Brohawn,Philip Z AU - Morehouse,Chris AU - Aoyama,Jordan AU - Wasserfall,Clive AU - Carter,Laura AU - Atkinson,Mark A AU - Serreze,David V AU - Braley-Mullen,Helen AU - Mustelin,Tomas AU - Kolbeck,Roland AU - Herbst,Ronald AU - Ettinger,Rachel TI - Autoimmune manifestations in aged mice arise from early-life immune dysregulation SN - 1946-6242 PY - 2017///1219 KW - Aging KW - Animals KW - Antibodies, Monoclonal KW - pharmacology KW - Autoantibodies KW - immunology KW - Autoimmunity KW - Bone Marrow Cells KW - metabolism KW - CD40 Antigens KW - genetics KW - CD40 Ligand KW - antagonists & inhibitors KW - Cytokines KW - Diabetes Mellitus, Experimental KW - Disease Models, Animal KW - Female KW - Immune System KW - pathology KW - Ligands KW - Lymphocytes KW - Mice KW - Mice, Inbred NOD KW - Salivary Glands KW - Sjogren's Syndrome KW - Spleen KW - Thyroiditis, Autoimmune N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural UR - https://doi.org/10.1126/scitranslmed.aag0367 ER -